![]() Active ingredients are rapidly released in liquid form as soon as the gelatin shell ruptures. Soft encapsulation of drugs further provides the potential to improve the bioavailability of pharmaceutical agents. Soft capsules are also more easily transported by patients than bulk liquids, since only the required number of doses need be removed from the package. Soft capsules, most commonly, soft gelatin capsules, provide a dosage form which is more readily accepted by patients, since the capsules are easy to swallow and need not be flavored in order to mask the unpleasant taste of the active agent. Such uniformity is more difficult to achieve via a tableting process wherein solids must be uniformly mixed and compressed, or via incorporation of the total dose of active ingredient into a bulk liquid carrier which must be measured out prior to each oral administration. Encapsulation of a solution or dispersion permits accurate delivery of a unit dose, an advantage which becomes especially important when relatively small amounts of the active ingredient must be delivered, as in the case of certain hormones. BACKGROUND OF THE INVENTIONĮncapsulation within a soft capsule of a solution or dispersion of a nutritional or pharmaceutical agent in a liquid carrier offers many advantages over other dosage forms such as compressed, coated or uncoated solid tablets or bulk liquid preparations. More specifically, it relates to novel compositions that are capable of forming films from which soft capsule shells can be made. This invention relates to capsules and, more specifically, to soft capsules typically made using a rotary die apparatus. ![]() This application is a continuation-in-part application and is based on U.S. ![]()
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